Vitamin D Deficiency Leads to Dementia

Category: Aging 266 0

Dementia is one of the major causes of disability and dependency among older people worldwide, affecting thinking and behaviors as you age. But what if you could stop this degenerative disease in its tracks?  The study is a reality as new genetic research shows a direct link between dementia and a lack of vitamin D.

Investigating the association between vitamin D, neuroimaging features, and the risk of brain health and stroke, the study found:

  • low levels of vitamin D were associated with lower brain volumes and an increased risk of dementia and stroke
  • genetic analyses supported a causal effect of vitamin D deficiency and dementia.
  • in some populations as much as 17 per cent of dementia cases might be prevented by increasing everyone to normal levels of vitamin D (50 nmol/L).

Dementia is a chronic or progressive syndrome that leads to deterioration in cognitive function. Globally, more than 55 million people have the condition with 10 million new cases diagnosed every year. The findings are important for the prevention of dementia and appreciating the need to abolish vitamin D deficiency.

“Vitamin D is a hormone precursor that is increasingly recognized for widespread effects, including on brain health, but until now it has been very difficult to examine what would happen if we were able to prevent vitamin D deficiency,” Prof Hyppönen says.

“Our study is the first to examine the effect of very low levels of vitamin D on the risks of dementia and stroke, using robust genetic analyses among a large population.

“In some contexts, where vitamin D deficiency is relatively common, our findings have important implications for dementia risks. Indeed, in this UK population we observed that up to 17 per cent of dementia cases might have been avoided by boosting vitamin D levels to be within a normal range.”

The findings are incredibly significant given the high prevalence of brain health issues around the world.

“Dementia is a progressive and debilitating disease that can devastate individuals and families alike,” Prof Hyppönen says.

“If we’re able to change this reality through ensuring that none of us is severely vitamin D deficient, it would also have further benefits and we could change the health and wellbeing for thousands.”

“Most of us are likely to be ok, but for anyone who for whatever reason may not receive enough vitamin D from the sun, modifications to diet may not be enough, and supplementation may well be needed.”

Source: University of South Australia

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